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. 2015 Aug 10;290(41):24689–24704. doi: 10.1074/jbc.M115.651653

TABLE 5.

Inhibition of receptor phosphorylation

IC50 (values in nm) are calculated using GraphPad Prism 6 software. NF indicates no fit is used when either Prism does not return a value (e.g. “ambiguous”) or the fit is poor (95% confidence interval range is >4-fold). ND = not determined.

Molecule and receptor H292
SNU-5
H1993
IC50 S.E. n IC50 S.E. n IC50 S.E. n
JNJ-61186372
    Phosphorylated EGFR 29 ND 1 15 2.8 2 3.8 0.22 3
    Phosphorylated c-MET 0.86 0.067 3 NF ND 2 7.8 2.6 3

EGFR × gp120
    Phosphorylated EGFR 13 1.1 4 NF ND 2 10 0.15 2
    Phosphorylated c-MET NF ND 2 NF ND 2 NF ND 2

c-MET × gp120
    Phosphorylated EGFR NF ND 4 NF ND 2 NF ND 2
    Phosphorylated c-MET 4.1 0.15 2 NF ND 2 7.8 ND 1

EGFR × gp120 + c-MET × gp120
    Phosphorylated EGFR 13 ND 1 NF ND 2 9.2 0.21 2
    Phosphorylated c-MET 2.8 ND 1 NF ND 2 12 ND 1
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