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Rx1(1–489) induces localized DNA melting. DNA remaining undigested after treatment with P1 nuclease in the presence of BSA, Rx1(1–489)WT, Rx1(1–489)K176R, or ORC as a percentage of total DNA (means ± S.E. (error bars); n = 6–19; *, p < 0.05 compared with dsDNA in the presence of BSA by one-way ANOVA with post hoc Dunnett test). The inset shows a control EMSA using the C3/mORB dual site DNA sequence at oriC2 of S. solfataricus in the presence or absence of 1.5 μm ORC.
