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. 2015 Aug 13;290(41):25045–25061. doi: 10.1074/jbc.M115.648592

FIGURE 5.

FIGURE 5.

ATP6ap2 expression and GSIS in human islets from normal and diabetic donors. A, representative images and quantitative analysis (quantification of fluorescence intensity and distribution of fluorescence intensity within cell population) of ATP6ap2 expression in human islets from normal and diabetic donors. Bar, 20 μm. B, ATP6ap2 expression in human dispersed islets from diabetic donors. Arrow indicates reduced ATP6ap2 expression in insulin-positive cells. Bar, 10 μm. Quantitative analysis of ATP6ap2 expression in both insulin- and glucagon-positive cells is shown (normal donors, n = 3; diabetic donors, n = 2). C, glucose-stimulated insulin secretion in human islets from diabetic donors.