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. 2015 Aug 13;290(41):25045–25061. doi: 10.1074/jbc.M115.648592

FIGURE 9.

FIGURE 9.

Effect of knocking down ATP6ap2 on insulin granule acidification and proinsulin processing. A, ratio of proinsulin versus insulin in cells transfected with siATP6ap2. B, expression of PC1/3, PC2, and CPE in INS-1 cells transfected with siATP6ap2. The expression was presented as ratio over control. C, representative images and quantitative analysis of LysoTracker staining of INS1 cells transfected with scramble siRNA (control), siATP6ap2, and treated with bafilomycin A (10 nm). The values are represented by the averages ± S.E. from triplicates in three independent experiments. *, p < 0.05 (n = 3).