FIGURE 8.
Effects of β and γ knuckle domain mutations on Na+ self-inhibition. A, Iss/Ipeak values obtained in oocytes expressing αβγ (WT), αβP461Cγ, αβI469Cγ, or αβS474Cγ (n = 6–7). The black bar indicates that the Iss/Ipeak for αβP521Cγ was significantly greater than that of WT (p < 0.01). Boldface lines above the three bars show the mean Iss/Ipeak values for channels with the corresponding α subunit mutation (from Fig. 6). B, Iss/Ipeak values in oocytes expressing αβγ (WT), αβγP478Cγ, αβγL486C, or αβγT491C (n = 6–9). The black bar indicates that the Iss/Ipeak for αβγP478C was significantly greater than that of WT (p < 0.01). Lines above the three bars are as described in A.