Table1.

The effectiveness of C. sativus as a treatment for depression in animal models

Constituent	Animal	Doses	Results	References
Aqueous and ethanolic extract	Mice	(0.2–0.8 g/kg)	The aqueous and ethanolic extracts of stigma, reduced immobility time.	Hosseinzadeh et al., 2003
Aqueous and ethanolic extract , Crocin	Mice	(50–600 mg/kg)	Reduced immobility time and increased swimming time.	Hosseinzadeh et al., 2003
Aqueous and ethanolic extract ,Safranal	Mice	(0.15–0.5 mL/kg)	Reduced immobility time and increased swimming time.	Hosseinzadeh et al., 2003
Kaempferol	Mice	100 and 200 mg/kg	Reduced immobility behaviors	Hosseinzadeh et al., 2007