Table2.

The effectiveness of C. sativus as a treatment for depression in human studies.

Number of patients	Treatments	Time ofTreatment (weeks)	Results	References
30	Stigma of C. sativus30 mg/day	6	The effect of stigma of C. sativussimilar to imipramine in the treatment of mild to moderate depression	Akhondzadeh et al.,2004
40	Stigma of C. sativus30 mg/day	6	The outcome on the Hamilton depression rating scale Stigma of C. sativuscould produce a significantly better than the placebo	Akhondzadeh et al.,2005
40	Stigma of C. sativus30 mg/day	6	The effect of stigma of C. sativussimilar to fluoxetine in the treatment of mild to moderate depression	Noorbala et al.,2005
40	Petal of C. sativus30 mg/day	6	The outcome on the Hamilton depression rating scale Petal of C. sativuscould produce a significantly better than the placebo	Moshiri et al.,2006
40	Petal of C. sativus15 mg bid (morning and evening)	8	Petal of C. sativuswas found to be effective similar to fluoxetine in The treatment of mild to moderate depression	AkhondzadehBasti et al., 2007
60	C. sativus40 and 80 mg/day+ fluoxetine (30 mg)	6	Was effective to treatment of mild to moderate depressive disorders	Moosavi et al., 2014
40	Saffron(30 mg/day	6	Was effective as fluoxetine (40 mg/day) in improving depressive symptoms of patients who are suffering from major depressive disorder (MDD)	Shahmansouri et al., 2014