Table 2.
Effect of SAE, crocin and placebo on liver and kidney functioning in patients with schizophrenia, as mean ±SD
| Parameters Groups | Baseline | Week 2 | Week 6 | Week 12 | p | |
|---|---|---|---|---|---|---|
| AST | SAE | 34.6±9.3 | 25.1±5.4 | 22.7±5.1 | 37.5±7.2 | 0.165 |
| Crocin | 36.1±7.5 | 26.1±8.4 | 25.2±8.2 | 22.5±4.3 | ||
| Placebo | 29.6±8.9 | 22.1±8.2 | 20.5±5.2 | 19.6±5.6 | ||
| ALT | SAE | 21.4±10.3 | 22.5±8.8 | 20.7±8.1 | 20.7±7.4 | 0.651 |
| Crocin | 22.1±10.3 | 24.5±11.1 | 22.6±9.1 | 18.1±7.0 | ||
| Placebo | 18.9±8.4 | 21.0±9.6 | 19.7±6.4 | 19.9±7.3 | ||
| ALP | SAE | 242.4±68.5 | 265.2±54.3 | 258.4±48.8 | 251.9±60.6 | 0.531 |
| Crocin | 242.8±57.6 | 237.0±51.5 | 240.6±70.2 | 251.6±62.9 | ||
| Placebo | 250.3±55.6 | 232.9±47.2 | 219.9±66.2 | 242.2±61.1 | ||
| Urea | SAE | 26.9±8.2 | 28.4±6.9 | 27.1±10.9 | 26.2±10.4 | 0.204 |
| Crocin | 30.2±8..6 | 32.3±8.0 | 31.0±9.0 | 30.2±8.6 | ||
| Placebo | 28.1±6.8 | 30.9±6.7 | 31.5±6.8 | 32.6±12.6 | ||
| Creatinine | SAE | 0.9±0.1 | 1.0±0.1 | 1.0±0.1 | 1.0±0.1 | 0.702 |
| Crocin | 0.9±0.1 | 1.0±0.1 | 1.0±0.1 | 1.1±0.1 | ||
| Placebo | 1.0±0.1 | 1.0±0.1 | 1.0±0.1 | 1.1±0.1 | ||
AST: Aspartate aminotransferase; ALT:Alanine aminotransferase; ALP: Alkaline phosphatase