Figure 5A and C.

Time (s) spent in the center for animals treated with crocetin (12.5, 25 and 50 mg/kg, i.p.) and crocin (25, 50 and 100 mg/kg, i.p.) in the open field test (OFT). B and D: Number of crossed squares for animals treated with crocetin (10, 20 and 40 mg/kg, i.p.) and crocin (10, 20 and 40 mg/kg, i.p.). The results are presented as mean ± SEM of 6 animals/group and were evaluated by one-way ANOVA. Positive control mice were treated with fluoxetine (10 mg/kg) and desipiramine (10 mg/kg)