Table 2. Top 10 up- and down-regulated genes by androgen.
| 4 hr (vs. Vehicle) | 48 hr (vs. Vehicle) | |
|---|---|---|
| Up-regulated (Fold) | RASSF9 (4.84) | BMPER (12.33) |
| AFMID (4.49) | TFCP2L1 (10.42) | |
| RICTOR (4.09) | SV2B (10.31) | |
| SQSTN1 (2.92) | CRISPLD2 (9.95) | |
| NOG (2.81) | SVIL (9.66) | |
| ERBB4 (2.80) | CES1 (9.05) | |
| CEBPD (2.73) | TUBB4B (8.69) | |
| MAP4K4 (2.66) | FGL2 (8.43) | |
| PLEKHF2 (2.55) | ENPP1 (8.21) | |
| NF2 (2.51) | SULT1A1 (6.74) | |
| Down-Regulated (Fold) | NPPA (-5.72) | RGD1560633 (-11.18) |
| BMP15 (-4.58) | CXCR4 (-9.28) | |
| APOC2 (-3.47) | PTGER3 (-6.76) | |
| LPAR2 (-3.08) | TMEM26 (-5.81) | |
| NKX2-3 (-2.97) | KCNA6 (-5.58) | |
| OXT (-2.93) | CPXM2 (-5.57) | |
| NR1H2 (-2.87) | AP3D1 (-5.39) | |
| FBXO32 (-2.77) | GTPBP1 (-5.36) | |
| PTAFR (-2.64) | PTGS2 (-5.21) | |
| TAC1 (-2.61) | UPK2 (-4.86) |
LASCs were seeded, allowed to attach 24 hours, treated with vehicle (DMSO) or NARA (10 nM) and incubated for 4 or 48 hours. Isolated cell mRNA was reverse transcribed into cDNA, labeled, and analyzed using DNA microarray. Data analysis was performed using Qiagen IPA software with cutoffs set at an FDR ≥ 0.2 and fold change ≥ 1.4. Fold change in parentheses.