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. 2015 Apr 17;2(1):e000022. doi: 10.1136/bmjgast-2014-000022

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions

This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/

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A high-fibre intervention elevates keratin level. Panel A graphical protocol: participants were recruited to an 8-week fibre intervention. Biopsies, food diary and faecal samples were collected at baseline and at exit from the intervention. Non-starch polysaccharide intake was significantly increased (panel B), however, there were no significant effects on faecal acetate or butyrate (Ci, Ciii) whereas propionate (Cii) approached a significant reduction. Levels of keratins 8 and 19 were measured by immunoblot, in samples preintervention and postintervention. Owing to effects of SCFAs and diet on ‘housekeeping’ markers (not shown), Coomassie staining of duplicate gels was used to show controlled loading of gels.