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. 2015 May 18;2(1):e000024. doi: 10.1136/bmjgast-2014-000024

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This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/

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Analysis of individual variation in unpooled samples in response to inflammation. Corresponding formalin-fixed paraffin embedded (FFPE) sections were stained and scored for keratins identified in this study. Colonic epithelial average surface and crypt intensity for K8 (top panel), K18 (centre panel) and K19 (bottom panel) were scored comparing patients with: active colitis (ACT), reciprocal proximal inactive colonic mucosa (INACT) from the same individuals, long-standing pancolitis (LSPC), recent-onset ulcerative colitis (UC) (ROUC), UC with concomitant primary sclerosing cholangitis (PSC), UC with dysplasia, and rectal sample from UC with dysplasia (DR); FFPE rectal tissues from normal individuals were immunohistochemical staining for each keratin as control (CON). Each group was compared with the CON and the statistically significant difference marked with a (*) sign at the top. *p<0.05, Mann-Whitney U test.