Table S2.

Assessment of reporting quality

	General risk of bias items						Control items				Treatment items
	Demographics reported	Baseline depression severity reported	Antidepressant use reported	Antidepressant use excluded	Adult MDD (>17 years and <60 years)	Concomitant medications reported	Similarly aged controls	Similar gender proportion in controls	Similar in other characteristics	Likelihood of high overall quality	Treated group demographics reported	All patients used same antidepressant	Change in depression noted	Likelihood of high overall quality
Bilici, 20001	+	+	+	+	+	+	+	?	+	+	+	−	+	+
Galecki et al2	+	+	+	+	+	+	+	+	+	+	+	+	+	+
Ghodake et al3	?	−	+	+	+	+	?	?	?	?	?	−	−	−
Khanzode et al4	+	+	+	+	+	?	+	?	?	+	+	−	+	+
Kotan et al5	+	+	+	+	+	+	+	+	+	+	+	−	+	+
Baek and Park6	+	+	−	−	+	−	+	+	+	+
Bajpai et al7	?	−	+	+	+	+	+	+	?	+
Bal et al8	+	−	+	+	+	+	+	+	+	+
Dimopoulos et al9	+	+	+	+	?	−	+	+	+	+
Fadillioglu et al10	+	+	−	−	+	−	+	+	+	?
Maes et al11	+	+	+	−	+	?	+	+	+	+
Maes et al12	+	+	+	−	+	+	+	+	+	+
Rybka et al13	+	+	+	−	+	−	+	+	+	+
Selley, 200314	+	−	+	+	+	?	+	+	+	+
Stefanescu and	+	+	+	−	+	?	+	+	+	+
Ciobica15
Vargas et al16	+	+	−	?	+	−	+	+	+	+
Yager et al17	+	−	+	+	+	+	+	+	+	+

Note: The + represents that the study met that criterion, – represents that the study did not meet that criterion, ? represents that it was unclear whether the study met that criterion.

Abbreviation: MDD, major depressive disorder.