Table II.
Specification Sheet of breast cancer tissue array-analysis.
| Pos | No. | Gender | Age (years) | Organ | Pathology diagnosis | Grade | Stage | TNM | ER | PR | HER2 | Typea |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A1 | 1 | F | 42 | Breast | Normal breast tissue (hyalinosis) | - | - | - | N/A | - | N/A | NAT |
| A2 | 2 | F | 42 | Breast | Normal breast tissue | - | - | - | - | - | 0 | NAT |
| A3 | 3 | F | 28 | Breast | Plasma cell mastitis | - | - | - | - | - | 0 | Inflammation |
| A4 | 4 | F | 28 | Breast | Plasma cell mastitis | - | - | - | - | - | 0 | Inflammation |
| A5 | 5 | F | 32 | Breast | Plasma cell mastitis | - | - | - | +, 4% | +, 5% | 0 | Inflammation |
| A6 | 6 | F | 32 | Breast | Plasma cell mastitis | - | - | - | - | - | 0 | Inflammation |
| A7 | 7 | F | 35 | Breast | Plasma cell mastitis | - | - | - | - | - | 0 | Inflammation |
| A8 | 8 | F | 35 | Breast | Plasma cell mastitis | - | - | - | - | - | 0 | Inflammation |
| A9 | 9 | F | 28 | Breast | Adenosis | - | - | - | +, 40% | +, 40% | 0 | Benign |
| A10 | 10 | F | 28 | Breast | Adenosis | - | - | - | - | - | 0 | Benign |
| A11 | 11 | F | 49 | Breast | Adenosis | - | - | - | ++, 30% | +, 35% | 0 | Benign |
| A12 | 12 | F | 49 | Breast | Adenosis | - | - | - | ++, 88% | 0,0085 | 0 | Benign |
| B1 | 13 | F | 44 | Breast | Adenosis | - | - | - | ++, 8% | ++, 70% | 1+ | Benign |
| B2 | 14 | F | 44 | Breast | Adenosis | - | - | - | +, 5% | ++, 3% | 0 | Benign |
| B3 | 15 | F | 58 | Breast | Fibroadenoma | - | - | - | - | - | 0 | Benign |
| B4 | 16 | F | 58 | Breast | Fibroadenoma | - | - | - | - | - | 0 | Benign |
| B5 | 17 | F | 22 | Breast | Fibroadenoma | - | - | - | ++, 10% | ++, 10% | 0 | Benign |
| B6 | 18 | F | 22 | Breast | Fibroadenoma | - | - | - | 0,0096 | +++, 70% | 0 | Benign |
| B7 | 19 | F | 54 | Breast | Fibroadenoma | - | - | - | - | - | 0 | Benign |
| B8 | 20 | F | 54 | Breast | Fibroadenoma | - | - | - | - | - | 0 | Benign |
| B9 | 21 | F | 34 | Breast | Invasive ductal carcinoma | 1 | IIb | T2N1M0 | - | - | 1+ | Malignant |
| B10 | 22 | F | 34 | Breast | Invasive ductal carcinoma | 1 | IIb | T2N1M0 | - | - | 1+ | Malignant |
| B11 | 23 | F | 43 | Breast | Invasive ductal carcinoma | 1 | IIb | T3N0M0 | - | - | 2+ | Malignant |
| B12 | 24 | F | 43 | Breast | Invasive ductal carcinoma | 1 | IIb | T3N0M0 | - | - | 2+ | Malignant |
| C1 | 25 | F | 40 | Breast | Invasive ductal carcinoma | 1 | IIb | T2N1M0 | N/A | N/A | N/A | Malignant |
| C2 | 26 | F | 40 | Breast | Invasive ductal carcinoma | 1 | IIb | T2N1M0 | +, 60% | - | 0 | Malignant |
| C3 | 27 | F | 50 | Breast | Invasive ductal carcinoma | 1 | IIb | T3N0M0 | - | - | 1+ | Malignant |
| C4 | 28 | F | 50 | Breast | Invasive ductal carcinoma | 1 | IIb | T3N0M0 | - | - | 1+ | Malignant |
| C5 | 29 | F | 37 | Breast | Invasive ductal carcinoma | 1 | IIa | T2N0M0 | - | - | 0 | Malignant |
| C6 | 30 | F | 37 | Breast | Invasive ductal carcinoma | 1 | IIa | T2N0M0 | - | - | 0 | Malignant |
| C7 | 31 | F | 46 | Breast | Invasive ductal carcinoma | 1 | IIIa | T3N2M0 | - | - | 2+ | Malignant |
| C8 | 32 | F | 46 | Breast | Invasive ductal carcinoma (fibrous tissue and blood vessel) | - | IIIa | T3N2M0 | - | - | 1+ | Malignant |
| C9 | 33 | F | 69 | Breast | Invasive ductal carcinoma (fibrofatty tissue and blood vessel) | - | IIa | T2N0M0 | - | - | 0 | Malignant |
| C10 | 34 | F | 69 | Breast | Invasive ductal carcinoma | 1 | IIa | T2N0M0 | - | - | 0 | Malignant |
| C11 | 35 | F | 52 | Breast | Invasive ductal carcinoma | 1 | IIIb | T4N1M0 | - | - | 1+ | Malignant |
| C12 | 36 | F | 52 | Breast | Invasive ductal carcinoma | 1 | IIIb | T4N1M0 | - | - | 1+ | Malignant |
| D1 | 37 | F | 65 | Breast | Invasive ductal carcinoma | 2 | IV | T3N1M1 | - | - | 1+ | Malignant |
| D2 | 38 | F | 65 | Breast | Invasive ductal carcinoma | 2 | IV | T3N1M1 | - | - | 1+ | Malignant |
| D3 | 39 | F | 45 | Breast | Invasive ductal carcinoma | 2 | IIa | T2N0M0 | +, 50% | ++, 90% | 0 | Malignant |
| D4 | 40 | F | 45 | Breast | Invasive ductal carcinoma | 2 | IIa | T2N0M0 | +, 65% | ++, 95% | 0 | Malignant |
| D5 | 41 | F | 37 | Breast | Invasive ductal carcinoma | 1 | IIIa | T3N1M0 | - | - | 1+ | Malignant |
| D6 | 42 | F | 37 | Breast | Invasive ductal carcinoma | 1 | IIIa | T3N1M0 | - | - | 1+ | Malignant |
| D7 | 43 | F | 55 | Breast | Invasive ductal carcinoma | 2 | IIb | T2N1M0 | - | - | 0 | Malignant |
| D8 | 44 | F | 55 | Breast | Invasive ductal carcinoma | 2 | IIb | T2N1M0 | - | - | 0 | Malignant |
| D9 | 45 | F | 55 | Breast | Invasive ductal carcinoma | 2 | IIIb | T4N1M0 | - | - | 1+ | Malignant |
| D10 | 46 | F | 55 | Breast | Invasive ductal carcinoma | 2 | IIIb | T4N1M0 | - | - | 1+ | Malignant |
| D11 | 47 | F | 75 | Breast | Invasive ductal carcinoma | 2 | IIb | T2N1M0 | - | - | 0 | Malignant |
| D12 | 48 | F | 75 | Breast | Invasive ductal carcinoma | 2 | IIb | T2N1M0 | - | - | 0 | Malignant |
| E1 | 49 | F | 41 | Breast | Invasive ductal carcinoma | 2 | IIa | T2N0M0 | - | +, 8% | 0 | Malignant |
| E2 | 50 | F | 41 | Breast | Invasive ductal carcinoma | 2 | IIa | T2N0M0 | - | +, 5% | 0 | Malignant |
| E3 | 51 | F | 44 | Breast | Invasive ductal carcinoma | 2 | IIb | T2N1M0 | - | - | 2+ | Malignant |
| E4 | 52 | F | 44 | Breast | Invasive ductal carcinoma (sparse) | 1 | IIb | T2N1M0 | - | - | 1+ | Malignant |
| E5 | 53 | F | 37 | Breast | Invasive ductal carcinoma | 2 | IIb | T3N0M0 | - | - | 1+ | Malignant |
| E6 | 54 | F | 37 | Breast | Invasive ductal carcinoma | 2 | IIb | T3N0M0 | - | - | 1+ | Malignant |
| E7 | 55 | F | 61 | Breast | Invasive ductal carcinoma | 2 | IIb | T2N1M0 | ++, 90% | - | 0 | Malignant |
| E8 | 56 | F | 61 | Breast | Invasive ductal carcinoma | 2 | IIb | T2N1M0 | ++, 95% | 0,20% | 0 | Malignant |
| E9 | 57 | F | 38 | Breast | Invasive ductal carcinoma (sparse) | 2 | IIb | T3N0M0 | - | - | 0 | Malignant |
| E10 | 58 | F | 38 | Breast | Invasive ductal carcinoma | 2 | IIb | T3N0M0 | - | - | 0 | Malignant |
| E11 | 59 | F | 65 | Breast | Invasive ductal carcinoma | 2 | IIa | T2N0M0 | +++, 100% | +++, 97% | 0 | Malignant |
| E12 | 60 | F | 65 | Breast | Invasive ductal carcinoma | 2 | IIa | T2N0M0 | +++, 99% | +++, 99% | 0 | Malignant |
| F1 | 61 | F | 53 | Breast | Invasive ductal carcinoma (sparse) | 2 | IIa | T2N0M0 | - | - | 1+ | Malignant |
| F2 | 62 | F | 53 | Breast | Invasive ductal carcinoma | 2 | IIa | T2N0M0 | - | - | 1+ | Malignant |
| F3 | 63 | F | 32 | Breast | Invasive ductal carcinoma | 2 | IIb | T2N1M0 | - | - | 1+ | Malignant |
| F4 | 64 | F | 32 | Breast | Invasive ductal carcinoma | 2 | IIb | T2N1M0 | - | - | 0 | Malignant |
| F5 | 65 | F | 56 | Breast | Invasive ductal carcinoma | 2 | IIb | T2N1M0 | - | - | 1+ | Malignant |
| F6 | 66 | F | 56 | Breast | Invasive ductal carcinoma | 2 | IIb | T2N1M0 | - | - | 1+ | Malignant |
| F7 | 67 | F | 52 | Breast | Invasive ductal carcinoma (sparse) | 2 | IIIa | T2N2M0 | +++, 98% | - | 0 | Malignant |
| F8 | 68 | F | 52 | Breast | Invasive ductal carcinoma | 2 | IIIa | T2N2M0 | ++, 75% | - | 0 | Malignant |
| F9 | 69 | F | 37 | Breast | Invasive ductal carcinoma | 3 | IIb | T2N1M0 | - | - | 0 | Malignant |
| F10 | 70 | F | 37 | Breast | Invasive ductal carcinoma | 3 | IIb | T2N1M0 | - | - | 0 | Malignant |
| F11 | 71 | F | 42 | Breast | Invasive ductal carcinoma | 2 | IIa | T2N0M0 | - | - | 1+ | Malignant |
| F12 | 72 | F | 42 | Breast | Invasive ductal carcinoma | 2 | IIa | T2N0M0 | - | - | 1+ | Malignant |
| G1 | 73 | F | 54 | Breast | Invasive ductal carcinoma | 2 | IIb | T3N0M0 | - | - | 2+ | Malignant |
| G2 | 74 | F | 54 | Breast | Invasive ductal carcinoma | 2 | IIb | T3N0M0 | - | - | 2+ | Malignant |
| G3 | 75 | F | 40 | Breast | Invasive ductal carcinoma | 3 | IIb | T2N1M0 | - | - | 0 | Malignant |
| G4 | 76 | F | 40 | Breast | Invasive ductal carcinoma | 3 | IIb | T2N1M0 | - | - | 0 | Malignant |
| G5 | 77 | F | 59 | Breast | Invasive ductal carcinoma | 2 | IIIa | T2N2M0 | - | - | 1+ | Malignant |
| G6 | 78 | F | 59 | Breast | Invasive ductal carcinoma | 2 | IIIa | T2N2M0 | - | - | 1+ | Malignant |
| G7 | 79 | F | 42 | Breast | Invasive ductal carcinoma | 3 | IIIb | T4N0M0 | - | - | 0 | Malignant |
| G8 | 80 | F | 42 | Breast | Invasive ductal carcinoma | 3 | IIIb | T4N0M0 | - | - | 0 | Malignant |
| G9 | 81 | F | 54 | Breast | Invasive ductal carcinoma | 3 | IIa | T2N0M0 | +++, 100% | ++, 5% | 0 | Malignant |
| G10 | 82 | F | 54 | Breast | Invasive ductal carcinoma | 3 | IIa | T2N0M0 | +++, 100% | +++, 3% | 0 | Malignant |
| G11 | 83 | F | 60 | Breast | Invasive ductal carcinoma | 3 | IIb | T2N1M0 | - | - | 0 | Malignant |
| G12 | 84 | F | 60 | Breast | Invasive ductal carcinoma | 3 | IIb | T2N1M0 | - | - | 0 | Malignant |
| H1 | 85 | F | 49 | Breast | Invasive ductal carcinoma | 2 | IIIa | T2N2M0 | +, 80% | +, 50% | 3+ | Malignant |
| H2 | 86 | F | 49 | Breast | Invasive ductal carcinoma | 2 | IIIa | T2N2M0 | +, 50% | +, 40% | 1+ | Malignant |
| H3 | 87 | F | 27 | Breast | Invasive ductal carcinoma | 2 | IIIb | T4N2M0 | - | - | 2+ | Malignant |
| H4 | 88 | F | 27 | Breast | Invasive ductal carcinoma | 2 | IIIb | T4N2M0 | - | - | 2+ | Malignant |
| H5 | 89 | F | 49 | Breast | Invasive ductal carcinoma | 2 | IIa | T2N0M0 | - | - | 2+ | Malignant |
| H6 | 90 | F | 49 | Breast | Invasive ductal carcinoma | 2 | IIa | T2N0M0 | - | - | 2+ | Malignant |
| H7 | 91 | F | 71 | Breast | Invasive ductal carcinoma | 3 | IIb | T2N1M0 | - | - | 0 | Malignant |
| H8 | 92 | F | 71 | Breast | Invasive ductal carcinoma | 3 | IIb | T2N1M0 | - | - | 0 | Malignant |
| H9 | 93 | F | 50 | Breast | Invasive lobular carcinoma | - | IIIa | T2N2M0 | +++, 90% | ++, 10% | 0 | Malignant |
| H10 | 94 | F | 50 | Breast | Invasive lobular carcinoma | - | IIIa | T2N2M0 | +++, 85% | ++, 1% | 0 | Malignant |
| H11 | 95 | F | 42 | Breast | Invasive lobular carcinoma | - | IIb | T2N1M0 | ++, 60% | +++, 60% | 0 | Malignant |
| H12 | 96 | F | 42 | Breast | Invasive lobular carcinoma | - | IIb | T2N1M0 | ++, 65% | +++, 40% | 0 | Malignant |
| - | - | M | 42 | Adrenal gland | Pheochromocytoma (tissue marker) | - | Malignant |
a
For precise diagnosis, refer to pathology description. The grade 1–3 (or I–III) in Pathology Diagnosis is equivalent to well-differentiated, moderately-differentiated or poorly differentiated, respectively, under microscope. Grade 1 or well-differentiated, cells appear normal and are not growing rapidly. Grade 2 or moderately-differentiated: cells appear slightly different than normal. Grade 3 or poorly differentiated, cells appear abnormal and tend to grow and spread more aggressively. Grade 4 or undifferentiated, *(for certain tumors), features are not significantly distinguishing to make it look any different from undifferentiated cancers which occur in other organs. Staining scoring: −, no staining; +−, borderline staining; +, weak staining; ++, moderate staining; +++, strong staining; %, percentage of positive cells. TNM grading: T, primary tumor; Tx, primary tumor cannot be assessed; T0, no evidence of primary tumor; Tis, carcinoma in situ; intraepithelial or invasion of lamina propria; T1, tumor invades submucosa; T2, tumor invades muscularis propria; T3, tumor invades through muscularis propria into subserosa or into non-peritonealized pericolic or perirectal tissues; T4, tumor directly invades other organs or structures and/or perforate visceral peritoneum; N, regional lymph nodes; Nx, regional lymph nodes cannot be assessed; N0, no regional lymph node metastasis; N1, metastasis in 1 to 3 regional lymph nodes; N2, metastasis in 4 or more regional lymph nodes; M, distant metastasis; Mx, distant metastasis cannot be assessed; M0, no distant metastasis; M1, distant metastasis.