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A., B. CST5- and C., D. p21-mRNA levels were measured by qPCR analysis at the indicated time points. A., C. HCT116 p53−/− or p53+/+ and B., D. RKO p53+/+ or p53−/− were treated with nutlin-3a or etoposide or the vehicle DMSO. Fold changes represent mean values of triplicate analyses of nutlin-3a/etoposide versus DMSO treated cells normalized to β-actin expression. Error bars represent standard deviations.
