Table 1. Summary of chromosomal copy number aberrations (CNAs) and status of IDH and MGMT genes in gliomas with total 1p19q loss by institutional diagnosis.
| Oligo (n=37) |
Astro (n=16) |
Unclassified low-grade glioma (n=4) |
|
|---|---|---|---|
| CNAs (detected in ≥10%) |
−1p19q (100%) −4q (24.3%) −14q (18.9%) −18q (18.9%) +11q or +11 (16.2%) −13q (13.5%) +17q (10.8%) +19p (10.8%) |
−1p19q (100%) +7q or +7 (31.2%) −4q (25%) +11q or +11 (18.8%) −18q (18.8%) +19p (18.8%) −9p (12.5%) +9q (12.5%) −10p (12.5%) −14q (12.5%) −15q (12.5%) +17q (12.5%) |
−1p19q(100%) −4(25%) −19p(25%) |
| IDH 1 mutation | 31/36(86.1%) | 12/13(92.3%) | 4/4(100%) |
| IDH 2 mutation | 3/3(100%) (Either IDH1 or IDH2 mutations in 34/34, 100%) |
0/1(0%) (Either IDH1 or IDH2 mutations in 12 of 13, 92.3%) |
Not performed |
| MGMT methylation | 21/32(65.6%) | 15/15(100%) | 2/4(50%) |
| ATRX loss | Not performed | 3/15(80%) | Not performed |
| P53 accumulation | Not performed | 0/15%(0%) | Not performed |