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. 2015 May 20;6(18):15882–15890. doi: 10.18632/oncotarget.4137

Figure 1. Histone methylations are changed with age but the age-associated change is prevented by DR and/or rapamycin treatment in mouse brain.

Figure 1

Representative western blots (upper) and quantitative densitometric analysis (lower) of H3K27me3 A., H3R2me2 B., H3K79me3 C. and H4K20me2 D. in brains from 3 months old ad libitum (Young), 22 months old ad libitum (Old), 22 months old dietary restricted (DR) and 22 months old rapamycin treatment (RAL) BALB/c mice. Histone modification levels were normalized to total H3 content. The values (mean±S.E.M.) are expressed as a percentage relative to the 3 months old group. n = 3~5 animals per goup. (**p < 0.01, *p < 0.05 Old versus Young, DR versus Old, RAL versus Old).