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. 2015 May 20;6(18):15882–15890. doi: 10.18632/oncotarget.4137

Figure 2. Distinctive impact of DR and/or rapamycin treatment on histone modifications in mouse brain.

Figure 2

Representative western blots (upper) and quantitative densitometric analysis (lower) of H3K18ac A., H3K4me2 B., H3K4me C., H3K27ac D., H4K16ac E., H4R3me2 F. and H3K56ac G. in brains from 3 months old ad libitum (Young), 22 months old ad libitum (Old), 22 months old dietary restricted (DR) and 22 months old rapamycin treatment (RAL) BALB/c mice. Histone modification levels were normalized to total H3 content. The values (mean±S.E.M.) are expressed as a percentage relative to the 3 months old group. n = 3~5 animals per goup. (**p < 0.01, *p < 0.05 Old versus Young, DR versus Old, RAL versus Old).