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. 2015 Apr 19;6(18):16106–16119. doi: 10.18632/oncotarget.3867

Figure 6. LAP1 represses HCC cell migration and invasion by inducing ORM2 expression.

Figure 6

A. SMMC-7721 and Li-7 cells overexpressing LAP1 were transiently transfected with siRNA targeted to ORM2 as indicated. QRT-PCR of ORM2 is shown in the left panel. The migration and invasion ability of the SMMC-7721 and Li-7 cells were assessed by transwell assays; cells transfected with the empty vector were used as a control. B. Representative immunostaining of C/EBPβ and ORM2 in HCC tissues (original magnification: left images, 40×; right images, 200×). C. The correlation between C/EBPβ and ORM2 protein expression in 236 HCC tissues was analyzed. r = 0.172, p = 0.008. **, p < 0.01, ***, p < 0.001.