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. 2015 Apr 20;6(18):16168–16182. doi: 10.18632/oncotarget.3753

Figure 5. ITLN1 attenuated the growth and metastasis of gastric cancer cells in vivo.

Figure 5

A and B. hypodermic injection of SGC-7901 cells into athymic nude mice established subcutaneous xenograft tumors. Four weeks later, mice (n = 5) from each group were sacrificed. Stable transfection of ITLN1 into cancer cells resulted in decreased tumor size (*P < 0.01 vs. mock), and the mean tumor weight formed from ITLN1 over-expressing cells was significantly decreased. C. SGC-7901 cells were injected into the tail vein of athymic nude mice (n = 5 for each group). Cancer cells stably transfected with ITLN1 established significantly fewer metastatic colonies (arrowhead). Scale bars: 100 μm. D and E. stable transfection of sh-ITLN1 into cancer cells resulted in increased tumor size (*P < 0.01 vs. sh-Scb), and the mean tumor weight formed from ITLN1 knockdown cells was significantly increased. F. cancer cells stably transfected with sh-ITLN1 established significantly more metastatic colonies (arrowhead), when compared to those transfected with sh-Scb. Scale bars: 100 μm.