Table 3. Univariate analyses of clinical prognostic factors and biomarkers (TMA I).
| Variable | HR for OS (95% CI) | p-value | HR for RFS (95% CI) | p-value* |
|---|---|---|---|---|
| Age | .997 (.979-1.015) | .723 | 1.040 (1.025-1.056) | <.0001 |
| Gender (M vs.F) | .813 (.549-1.203) | .300 | 1.324 (.981-1.786) | .066 |
| Race (white vs. other) | 2.123 (1.261-3.574) | .005 | 1.043 (.640-1.699) | .867 |
| Smoker (Ever vs. never) | .669 (418-1.072) | .095 | 1.136 (.754-1.712) | .542 |
| Histology (ADC vs. SCC) | .946 (.626-1.430) | .792 | 1.442 (1.068-1.949) | .017 |
| Stage (vs. I) | ||||
| II | 2.005 (1.201-3346) | .008 | 1.566 (1.069-2.293) | .021 |
| III/IV | 4.106 (2.557-6.593) | <.001 | 2.707 (1.365-5.370) | .004 |
| IGF-1R | ||||
| cytoplasmic | .998 (.993-1.003) | .381 | 1.000 (.997-1.003) | .961 |
| membrane | .995 (.988-1.003) | .238 | 1.000 (.995-1.005) | .962 |
| p-IGF-IR/1R | ||||
| cytoplasmic | 1.008 (.987-1.030) | .444 | 1.011 (.996-1.026) | .141 |
| membrane | 1.004 (.999-1.009) | .157 | 1.004 (.999-1.008) | .099 |
*
Univariate p-values are based on Cox Proportional Hazard Model.
Abbreviation: HR – hazard ratio, OS – overall survival, RFS – recurrence-free survival, CI – confidence interval, ADC – adenocarcinoma, SCC – squamous cell carcinoma, IR – insulin receptor and IGF-1R – insulin-like growth factor 1 receptor.