Table 4. Univariate analyses of clinical prognostic factors and biomarkers (TMA II).

Variable	HR for OS (95% CI)	p-value	HR for RFS (95% CI)	p-value*
Age	1.015 (0.998-1.031)	0.08	1.007 (0.993-1.022)	0.31
Gender (M vs.F)	1.468 (1.067-2.020)	0.0186	1.317 (0.997-1.740)	0.053
Race (white vs. other)	0.747 (0.457-1.222)	0.245	0.784 (0.504-1.222)	0.28
Smoker
Former vs. Never	1.045 (0.597-1.828)	0.88	1.081 (0.667-1.751)	0.75
Current vs. Never	1.219 (0.698-2.129)	0.49	1.108 (0.681-1.803)	0.68
Histology (ADC vs. SCC)	0.831 (0.600-1.151)	0.27	0.809 (0.609-1.074)	0.14
Stage (vs. I)
II	1.608 (1.090-2.374)	0.0157	1.73 (1.226-2.440)	0.0018
IIIA	2.399 (1.613-3.570)	<0.0001	2.734 (1.930-3.872)	<0.0001
IGF-IR
cytoplasmic	1.003 (0.999-1.007)	0.19	1.004 (1.000-1.008)	0.034
membrane	1.002 (0.992-1.011)	0.70	1.001 (0.992-1.010)	0.88
p-IGF-112/IR
cytoplasmic	0.997 (0.985-1.010)	0.50	0.990 (0.978-1.003)	0.12
membrane	0.998 (0.993-1.003)	0.41	0.997 0.992-1.001	0.16

^*Univariate p-values are based on Cox Proportional Hazard Model

Abbreviations: HR = Hazard Ratio, CI = Confidence interval, OS = overall survival, RFS: relapse-free survival.