Fig. 2.

Conservation differs for buried sites. The conservation differences in interacting (homodimer) sub-group between the three types of positions with sequence identity cut-off (Test-set 1). Average entropies were calculated to describe the difference. ‘Interface’, ‘Surface’ and ‘Buried’ stand for Interaction sites, other Surface and Buried inaccessible residues, respectively. Buried sites show distinctly lower entropy (higher conservation), but differences between surface and interface are negligible