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. Author manuscript; available in PMC: 2015 Oct 9.
Published in final edited form as: Nature. 2005 Jun 9;435(7043):828–833. doi: 10.1038/nature03552

Figure 2. Overexpression of the mir-17–19b cluster accelerates c-myc-induced lymphomagenesis in mice.

Figure 2

a, Schematic representation of the adoptive transfer protocol using Eμ-myc HSCs. b, Mice reconstituted with HSCs expressing mir-17–19b in an MSCV retroviral vector (MSCV mir-17–19b) or infected with a control MSCV virus were monitored by blood smear analysis starting 5 weeks after transplantation. The Kaplan-Meier curves represent the percentage of leukaemia-free survival or overall survival. c, External GFP imaging of tumour-bearing mice with Eμ-myc/mir-17–19b or Eμ-myc/MSCV shows the overall distribution of tumour cells. Eμ-myc/mir-17–19b tumours show a more disseminated phenotype compared with control tumours. These animals are representative of their genotype.