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. 2015 May 8;4(5):e001614. doi: 10.1161/JAHA.114.001614

Figure 1.

Figure 1

Mechanical dyssynchrony-prone cardiomyopathy model. Knockout of the Kcnj11-encoded Kir6.2 protein precipitates stress-induced cardiomyopathy with dyssynchrony. At 2 weeks post-TAC, Kcnj11-deficent left ventricles (KO) developed systolic dysfunction (A) with echocardiographic evidence of intraventricular delay in contractile timing (B through F), typical of mechanical dyssynchrony, in the absence of electrocardiographic change (G and H). *P<0.05 vs. Pre; †P<0.05 vs. WT 2 weeks post-TAC. KO indicates knockout; SD, standard deviation; TAC, transverse aortic constriction; WT, wild type.