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. 2015 May 8;4(5):e001614. doi: 10.1161/JAHA.114.001614

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© 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Protection of organ geometry and histology. Exaggerated cardiomegaly (A and B), fibrosis (C through F), and myocardial disarray (G through I) in response to [TAC-iPS(-)] was blunted by stem cell therapy [TAC-iPS(+)]. *P<0.05 vs. TAC(−); ^†P<0.05 vs. TAC-iPS(−). Bar represents 2 mm in (A). Ao indicates aorta; CI, confidence interval; DAPI, 4′,6′-diamidino-2-phenylindole; iPS, induced pluripotent stem; LA, left atrium; LV, left ventricle; RA, right atrium; RV, right ventricle; TAC, transverse aortic constriction; white arrow, LV free wall; yellow arrow, LV dimension; α-actinin, sarcomeric α-actinin.