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. 2015 May 8;4(5):e001614. doi: 10.1161/JAHA.114.001614

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© 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Protection of myofibrillar ultrastructure. Sarcomere ultrastructure at low- (A through C) and high-magnification (D through F) electron microscopy. Kir6.2-deficient left ventricles after 3 months of TAC demonstrated severe fibrosis [TAC-iPS(−); B] and lacked myofibrils (E). Cell-treated Kir6.2-deficient ventricles [TAC-iPS(+)] exhibited normal sarcomeres (C) with significant increase in myofibrils (F and G). *P<0.05 vs. TAC(−); ^†P<0.05 vs. TAC-iPS(−). CI indicates confidence interval; iPS, induced pluripotent stem; TAC, transverse aortic constriction.