Table 5.

Results of the Animal Study at 4 Weeks

	Sham+NS (n=8)	Sham+HS (n=8)	UNX+NS (n=8)	UNX+HS (n=8)	UNX+HS+IDP (n=8)
Water intake, mL/d	60.7±5.2	171.9±24.4	65.6±5.6	192.6±49.8	172.0±29.8
Food intake, g/d	30.6±3.1	31.5±2.7	30.3±1.6	32.2±4.3	31.2±2.3
Body weight, g	310.9±23.2	257.2±11.1	288.8±44.6	267.5±27.4	305.4±22.2
Urine volume, mL/d	24.4±5.5	122.6±15.3	30.0±4.7	141.7±38.2	130.1±21.8
Urine Na, mmol/L	95±42	320±16	105±9	251±26	320±71
ECW, L	0.067±0.010	0.067±0.008	0.070±0.010	0.065±0.009	0.072±0.009
TBW, L	0.186±0.023	0.178±0.022	0.188±0.030	0.163±0.021	0.195±0.022
ECW/TBW, %	37.4±0.9	37.5±0.7	37.2±1.0	40.3±0.9	37.3±1.2
SBP, mm Hg	101±3	102±4	98±5	134±11	102±6
UPCR, g/g	2.85±0.67	2.75±0.91	2.97±1.12	5.08±1.31	1.86±0.47
Serum TNF-α, pg/mL	6.78±1.08	7.40±2.34	10.88±2.79	17.80±7.04	10.46±2.55
Renal TNF-α, pg/μg	3.02±0.40	3.82±0.56	3.00±0.32	6.01±3.92	3.04±0.69

ECW indicates extracellular water; SBP, systolic blood pressure; Sham+NS, sham-operated rats raised with normal-salt diet; Sham+HS, sham-operated rats raised with high-salt diet; TBW, total body water; TNF-α, tumor necrosis factor α; UNX+NS, uninephrectomized rats raised with normal-salt diet; UNX+HS, uninephrectomized rats raised with high salt diet; UNX+HS+IDP, indapamide-treated UNX+HS rats; UPCR, urine protein–creatinine ratio.