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. 2015 May 6;4(5):e001920. doi: 10.1161/JAHA.115.001920

Figure 1.

Figure 1

HF attenuates hippocampus-independent, short-term memory. A, HF attenuated the rodents’ short-term retention of object familiarity in a nonspatial novel object recognition task with a 5-minute retention interval. B, The calculated DI revealed a clear preference for the familiar rather than the novel object in HF mice. C, All aspects of locomotor activity were shown not to be significantly different between sham and HF mice. For all tasks: sham n=9, HF n=10,*P<0.05. D, Cerebral protein expression of NMDAR2A (n=7, P=0.6494) and (E) PSD-95 (n=6, P=0.9074) was not affected during HF. Ac(S) indicates active time; Act, activity; Crear, center rearing; DI, discrimination index; Etn, etanercept; FR, front to back count; HF, heart failure; Mo(S), mobile time; MO, mobile counts; NMDAR, N-methyl-D-aspartate receptor; PSD-95, postsynaptic density protein 95; Rear, rearing; Rr(S), rearing time; SAct, slow activity; SCR, slow center rearing; SMO, slow mobile counts; SRr, slow rearing.