Table 2.
Risk of All-Cause Death
| Events/No. at Risk | Model 1* HR (95% CI) | P Value | Model 2† HR (95% CI) | P Value | Interaction‡ P Value | |
|---|---|---|---|---|---|---|
| Systolic blood pressure response | ||||||
| >20 mm Hg | 3283/37 128 | 1.0 | — | 1.0 | — | |
| 1 to 20 mm Hg | 1050/5548 | 1.64 (1.53, 1.76) | <0.001 | 1.13 (1.05, 1.22) | <0.001 | — |
| ≤0 mm Hg | 449/1413 | 2.07 (1.87, 2.29) | <0.001 | 1.21 (1.09, 1.34) | <0.001 | — |
| Per 1 SD decrease | 4782/44 089 | 1.31 (1.27, 1.34) | <0.001 | 1.08 (1.05, 1.11) | <0.001 | — |
| Age‖$ | ||||||
| <52 y | 909/22 317 | 1.61 (1.51, 1.71) | <0.001 | 1.17 (1.10, 1.26) | <0.001 | 0.009 |
| ≥52 y | 3873/21 772 | 1.47 (1.43, 1.51) | <0.001 | 1.11 (1.08, 1.15) | <0.001 | |
| Sex$ | ||||||
| Female | 1705/20 051 | 1.30 (1.24, 1.36) | <0.001 | 1.09 (1.04, 1.15) | <0.001 | 0.15 |
| Male | 3077/24 038 | 1.31 (1.27, 1.35) | <0.001 | 1.07 (1.04, 1.11) | <0.001 | |
| Race$ | ||||||
| Nonwhite | 1685/14 967 | 1.29 (1.23, 1.35) | <0.001 | 1.03 (0.98, 1.08) | 0.25 | 0.056 |
| White | 3097/29 122 | 1.31 (1.26, 1.35) | <0.001 | 1.10 (1.06, 1.14) | <0.001 | |
HR indicates hazard ratio; METs, metabolic equivalents of task.
*
Adjusted for age, sex, and race.
†
Adjusted for Model 1 covariates plus smoking, hypertension, diabetes, obesity, hyperlipidemia, antihypertensive medication use, lipid-lowering medication use, aspirin, METs, and chronotropic incompetence.
‡
Interactions tested using Model 2.
$
All HRs presented are for the systolic blood pressure response per 1 SD decrease and were computed without the interaction term in the model.
‖
Dichotomized at the median age for study participants.