Table 3.
Risk of Myocardial Infarction
| Events/No. at Risk | Model 1* HR (95% CI) | P Value | Model 2† HR (95% CI) | P Value | Interaction‡ P Value | |
|---|---|---|---|---|---|---|
| Systolic blood pressure response | ||||||
| >20 mm Hg | 867/37 128 | 1.0 | — | 1.0 | — | — |
| 1 to 20 mm Hg | 232/5548 | 1.54 (1.32, 1.78) | <0.001 | 1.09 (0.93, 1.27) | 0.28 | — |
| ≤0 mm Hg | 89/1413 | 1.93 (1.54, 2.41) | <0.001 | 1.19 (0.95, 1.50) | 0.14 | — |
| Per 1 SD decrease | 1188/44 089 | 1.30 (1.23, 1.37) | <0.001 | 1.09 (1.03, 1.16) | 0.003 | — |
| Age$‖ | ||||||
| <52 y | 308/22 317 | 1.44 (1.29, 1.61) | <0.001 | 1.11 (0.99, 1.25) | 0.081 | 0.71 |
| ≥52 y | 880/21 772 | 1.41 (1.33, 1.50) | <0.001 | 1.13 (1.05, 1.20) | <0.001 | |
| Sex‖ | ||||||
| Female | 399/20 051 | 1.31 (1.18, 1.44) | <0.001 | 1.10 (0.99, 1.22) | 0.078 | 0.60 |
| Male | 789/24 038 | 1.29 (1.21, 1.38) | <0.001 | 1.09 (1.02, 1.17) | 0.016 | |
| Race‖ | ||||||
| Nonwhite | 518/14 967 | 1.26 (1.17, 1.38) | <0.001 | 1.02 (0.94, 1.12) | 0.62 | 0.29 |
| White | 670/29 122 | 1.32 (1.23, 1.42) | <0.001 | 1.14 (1.06, 1.23) | <0.001 | |
HR indicates hazard ratio; METs, metabolic equivalents of task.
*
Adjusted for age, sex, and race.
†
Adjusted for Model 1 covariates plus smoking, hypertension, diabetes, obesity, hyperlipidemia, antihypertensive medication use, lipid-lowering medication use, aspirin, METs, and chronotropic incompetence.
‡
Interactions tested using Model 2.
$
Dichotomized at the median age for study participants.
‖
All HRs presented are for the systolic blood pressure response per 1 SD decrease and were computed without the interaction term in the model.