Figure 3.

TPN-Q prevents beneficial maintenance of myocyte contractility after stress by DZX. Isolated mouse myocytes were exposed to control Tyrode’s physiologic solution (TYR) for 5 minutes (time 0 to 5), stress (CPG, CPG+DZX, CPG+DZX+TPN-Q, CPG+TPN-Q, and TYR+TPN-Q) for 10 minutes (time 5 to 15), followed by TYR for 5 minutes (time 15 to 20). Myocyte contractility was compared. Data are represented as mean±SEM. *P<0.05 vs. TYR; ^ΨP<0.05 vs. CPG+DZX. CPG indicates hypothermic hyperkalemic cardioplegia; DZX, diazoxide; TPN-Q, tertiapin Q