Table 4.
Mortality Risk for Patients With and Without ICDs by Prior HFH
| HFH in Past 6 Months | No HFH in Past 6 Months | |||
|---|---|---|---|---|
| ICD (ICD Registry) | No ICD (GWTG-HF) | ICD (ICD Registry) | No ICD (GWTG-HF) | |
| n | 781 | 352 | 702 | 553 |
| Follow-up duration among survivors, y | ||||
| Median | 4.5 | 2.9 | 4.5 | 3.1 |
| 25th, 75th percentiles | 2.6, 5.1 | 1.2, 3.9 | 3.0, 5.0 | 2.0, 4.7 |
| Minimum, maximum | 0.014, 5.9 | 0.052, 6.7 | 0.016, 6.0 | 0.019, 6.7 |
| Total deaths | 489 | 237 | 385 | 324 |
| Mortality rate (KM) at 1 year, % (95% CI) | 27.9 (24.9 to 31.3) | 37.5 (32.6 to 42.9) | 16.9 (14.2 to 19.9) | 25.6 (22.1 to 29.6) |
| Mortality rate (KM) at 3 years, % (95% CI) | 51.5 (47.9 to 55.2) | 61.9 (56.5 to 67.4) | 41.2 (37.5 to 45.1) | 53.5 (49.1 to 58.1) |
| Mortality rate at 3 years for 1-year survivors, % (95% CI) | 32.7 (28.8 to 37.0) | 39.1 (32.4 to 46.6) | 29.3 (25.6 to 33.4) | 37.5 (32.6 to 42.9) |
| Adjusted mortality rate at 1 year, % (95% CI) | 26.4 (25.9 to 27.0) | 33.5 (32.8 to 34.1) | 20.3 (19.9 to 20.8) | 26.1 (25.6 to 26.6) |
| Adjusted mortality rate at 3 years, % (95% CI) | 51.9 (51.1 to 52.7) | 61.7 (60.9 to 62.6) | 42.1 (41.3 to 42.8) | 51.3 (50.5 to 52.1) |
| Adjusted HR (95% CI) for ICD vs no ICD | 0.69 (0.58 to 0.82) | 0.75 (0.65 to 0.86) | ||
| P value for HR | <0.0001 | <0.0001 | ||
| P value for interaction of subgroup with ICD | 0.46 | |||
GWTG-HF indicates Get With The Guidelines–Heart Failure; HFH, heart failure hospitalization; HR, hazard ratios; ICD, implantable cardioverter-defibrillator; KM, Kaplan–Meier.