Table 3.

Coronary Sinus and Transcoronary Gradient Plasma Concentrations of IL-1β and IL-18, by Colchicine Administration

	ACS				Stable CAD
	Colchicine	No Colchicine	Controls	P Value†	Colchicine	No Colchicine	Controls	P Value*
Number	21	19	10	—	13	20	10	—
CS IL-1β	8.95 (0.26)	13.42 (2.59)	7.88 (0.18)	0.024	8.54 (0.38)	9.29 (0.43)	7.88 (0.18)	0.074
Gradient IL-1β	0.87 (0.32)	3.75 (1.87)	−0.05 (0.17)	0.028	0.53 (0.41)	0.87 (0.38)	−0.05 (0.17)	0.313
CS IL-18	301.42 (18.17)	325.88 (24.49)	280.66 (30.25)	0.239	349.54 (41.21)	346.50 (40.46)	280.66 (30.25)	0.434
Gradient IL-18	22.85 (6.50)	38.20 (6.25)	9.33 (9.04)	0.032	32.42 (4.43)	28.14 (6.10)	9.33 (9.04)	0.077
CS IL-6	12.79 (2.97)	77.00 (26.28)	4.31 (0.42)	0.004	4.75 (0.86)	6.64 (1.07)	4.31 (0.42)	0.617
Gradient IL-16	6.02 (2.47)	53.90 (23.07)	1.01 (0.36)	0.032	0.29 (0.47)	2.20 (0.85)	1.01 (0.36)	0.057

All data: mean (SEM) (pg/mL). ACS indicates acute coronary syndrome; CS, coronary sinus; IL, interleukin; CAD, coronary artery disease.

^*Difference between ACS colchicine vs. ACS no colchicine vs. controls.

^†Difference between stable CAD colchicine vs. stable CAD no colchicine vs. controls.