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. 2015 Jul 31;4(8):e002272. doi: 10.1161/JAHA.115.002272

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© 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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ALAS2 TG mice have worsened cardiac function following coronary ligation. A, Representative M-mode echocardiographic images of ALAS2 NTG and TG mice are shown 28 days after sham thoracotomy or permanent coronary ligation (MI). B, EF and (C) FS are worsened in ALAS2 TG mice 28 days after MI compared to NTG littermates (n=4 to 5). D, HW to TL ratio is increased in ALAS2 TG mice 28 days after MI compared to NTG littermates (n=5 to 6). Data are presented as mean±SEM. *P<0.05. ALAS2 indicates δ-aminolevulinic acid synthase 2; EF, ejection fraction; FS, fractional shortening; HW, heart weight; MI, myocardial infarction; NTG, nontransgenic; TG, transgenic; TL, tibia length.