Table 3.
Mean Changes in Echocardiographic Parameters From Baseline to 12 Months
| CRT OFF | CRT ON | P Value | |||||||
|---|---|---|---|---|---|---|---|---|---|
| n | Baseline | 12-Month | Change (SD) | n | Baseline | 12-Month | Change (SD) | ||
| Eessb, mm Hg/mL | 146 | 0.82 | 0.79 | −0.03±0.44 | 321 | 0.86 | 0.91 | 0.05±0.45 | 0.052 |
| Stroke work, mL mm Hg | 163 | 6125 | 6100 | −26 (2232) | 343 | 6277 | 6147 | −123 (2289) | 0.63 |
| Stroke work/LVEDV, mm Hg | 163 | 23.4 | 23.9 | 0.5 (6.9) | 343 | 24.6 | 28.6 | 4.0 (9.6) | <0.0001 |
| PRSW, g/cm2 | 94 | 37.4 | 38.5 | 1.0 (13.6) | 172 | 40.4 | 43.6 | 3.2 (13.9) | 0.23 |
| Ea, mm Hg/mL | 163 | 1.77 | 1.70 | −0.06±0.60 | 343 | 1.78 | 1.80 | 0.01±0.65 | 0.20 |
| Ea/Eessb | 146 | 2.46 | 2.35 | −0.11±1.10 | 321 | 2.30 | 2.26 | −0.04±1.22 | 0.53 |
| V0, mL | 146 | 38.8 | 43.2 | 4±91 | 321 | 38.4 | 9.1 | −29±84 | 0.0001 |
| Stroke volume, mL | 165 | 69.2 | 69.5 | 0.3±21.8 | 344 | 69.8 | 68.7 | −1.1±21.9 | 0.50 |
| LVEDV, mL | 165 | 274 | 271 | −2±57 | 344 | 265 | 230 | −35±65 | <0.0001 |
| LVESV, mL | 165 | 204 | 202 | −2±48 | 344 | 195 | 161 | −34±57 | <0.0001 |
| LVEF, % | 165 | 26.3 | 27.1 | 0.8±6.6 | 344 | 27.3 | 31.8 | 4.6±9.3 | <0.0001 |
P value compares the mean changes (2-sample t test) between CRT OFF and CRT ON. CRT OFF indicates control group; CRT ON, active cardiac resynchronization therapy group; Ea, effective arterial elastance; Eessb, single beat–derived end-systolic elastance; LVEDV, left ventricular end-diastolic volume; LVEF, left ventricular ejection fraction; LVESV, left ventricular end-systolic volume; PRSW, preload recruitable stroke work; V0, volume intercept.