Table 4.
Durations and Target Temperatures With or Without Favorable Outcomes
| Initial Recorded Rhythm Was Shockable (n=126) | Out-of-Hospital Cardiac Arrest (n=193) | Acute Coronary Syndrome (n=97) | Conventional Cardiopulmonary Resuscitation (n=150) | Extracorporeal Cardiopulmonary Resuscitation (n=87) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Favorable (n=64) | Unfavorable (n=62) | P Value | Favorable (n=72) | Unfavorable (n=121) | P Value | Favorable (n=31) | Unfavorable (n=66) | P Value | Favorable (n=70) | Unfavorable (n=80) | P Value | Favorable (n=17) | Unfavorable (n=70) | P Value | |
| Cardiac arrest to CPR, min | 6 (2 to 9) | 6 (2 to 12) | 0.274 | 7 (2 to 9) | 6 (1 to 14) | 0.522 | 7 (1 to 11) | 4 (1 to 10) | 0.658 | 7 (2 to 10) | 10 (2 to 15) | 0.057 | 0 (0 to 5) | 2 (1 to 9) | 0.058 |
| Cardiac arrest to ROSC, min | 21 (15 to 29) | 49 (33 to 60) | <0.001 | 23 (15 to 35) | 48 (37 to 61) | <0.001 | 25 (19 to 36) | 44 (24 to 58) | 0.001 | 21 (15 to 30) | 42 (31 to 53) | <0.001 | 25 (18 to 44) | 51 (34 to 62) | 0.002 |
| ROSC to 34°C, min | 231 (127 to 401) | 108 (55 to 189) | <0.001 | 231 (136 to 373) | 109 (55 to 168) | <0.001 | 178 (105 to 320) | 94 (22 to 148) | 0.002 | 237 (151 to 394) | 153 (98 to 242) | <0.001 | 28 (6 to 90) | 34 (10 to 90) | 0.805 |
| Protocol | |||||||||||||||
| Target temperature <34°C | 26 (41) | 26 (42) | 0.881 | 26 (36) | 43 (36) | 0.936 | 17 (55) | 27 (41) | 0.199 | 22 (31) | 20 (25) | 0.381 | 14 (82) | 34 (49) | 0.012 |
| Cooling ≥28 h | 25 (39) | 19 (31) | 0.322 | 32 (44) | 38 (31) | 0.068 | 16 (52) | 20 (30) | 0.043 | 29 (41) | 31 (39) | 0.738 | 4 (24) | 11 (16) | 0.48 |
| Rewarming ≥28 h | 24 (38) | 21 (34) | 0.671 | 31 (43) | 43 (36) | 0.299 | 15 (48) | 24 (36) | 0.26 | 28 (40) | 32 (40) | 1.000 | 4 (24) | 15 (21) | 1.000 |
| Practical | |||||||||||||||
| Target temperature <34°C | 26 (41) | 26 (42) | 0.881 | 26 (36) | 43 (36) | 0.936 | 17 (55) | 27 (41) | 0.199 | 22 (31) | 20 (25) | 0.381 | 14 (82) | 34 (49) | 0.012 |
| Cooling, h | 24.6 (23.8 to 48.0) | 24.0 (6.4 to 26.4) | 0.009 | 25.8 (24.0 to 48.0) | 24.5 (12.9 to 36.5) | 0.002 | 26.0 (23.8 to 48.0) | 23.7 (6.2 to 31.9) | 0.005 | 24.9 (24.0 to 48.0) | 24.5 (23.1 to 48.0) | 0.269 | 23.7 (12.0 to 25.8) | 19.6 (5.6 to 25.1) | 0.13 |
| Rewarming, h | 23.0 (12.0 to 48.0) | 12.0 (0 to 24.3) | <0.001 | 25.3 (17.3 to 48.8) | 15.5 (0 to 29.5) | <0.001 | 26.0 (15.5 to 66.3) | 12.0 (0 to 45.8) | <0.001 | 24.0 (15.4 to 48.0) | 21.0 (11.0 to 46.1) | 0.052 | 12.0 (11.5 to 42.3) | 5 (0 to 19.0) | 0.002 |
CPR indicates cardiopulmonary resuscitation; ROSC, return of spontaneous circulation.