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. 2015 Sep 1;4(9):e002159. doi: 10.1161/JAHA.115.002159

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© 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Reduction of delayed rectifier K+ current (I_Kr) density in A561P-UhiPS CMs. A, Representative raw data of currents recorded from control UhiPS-CMs (left) and A561P-UhiPS-CMs (right); protocol is shown as inset (holding potential: −50 mV; stimulation frequency: 1/12.5 Hz; traces with test pulse from −40 to 0 mV are shown). Currents are shown before and after 1 μmol/L E-4031 application. E-4031-sensitive currents are considered as I_Kr. B, Tail current density measurement obtained on repolarization after test pulse at +60 mV in control UhiPS-CMs (n=13) and A561P-UhiPS CMs (n=11), highlighting a significant reduction in A561P-UhiPS CMs. Protocol is shown in inset. **P<0.01 vs control UhiPS-CMs. C, Voltage-dependent activation curves obtained by plotting the relative E-4031-sensitive current on repolarization at −50 mV (arrows in A) in control UhiPS-CMs (n=13) and A561P-UhiPS CMs (n=8) (arrows in A). CM indicates cardiomyocytes; Ctrl, control; UhiPS, urine-derived human induced pluripotent stem cells.