Table 1.
Effects of A561P Mutation on Delayed Rectifier K+ Current in UhiPS-CMs
| Control UhiPS-CMs | A561P-UhiPS CMs | |
|---|---|---|
| Tail current density(n) | 1.79±0.2 pA/pF(13) | 0.89±0.1 pA/pF**(11) |
| Activation | ||
| V1/2 | −26.49±1.7 mV | −23.81±1.5 mV |
| k(n) | 7.75±0.7 mV(13) | 7.1±0.7 mV(8) |
The tail current density was measured at −50 mV following a depolarization to +60 mV. CMs indicates cardiomyocytes; k, slope factor (see protocol in Figure 4A); pA, current amplitude; pF, cell membrane capacitance; UhiPS, urine-derived human induced pluripotent stem cells; V1/2, prepulse voltage for which the tail current is half of its maximal value.
**
P<0.01 vs control UhiPS-CMs.