Table 6.
Reclassification Metric | Model for CVD | |||||
---|---|---|---|---|---|---|
CVD Risk Factors | +LVMI | +LVM/LVEDV | +RWT | +LVMI and LVM/LVEDV | +LVMI and RWT | |
C-statistic value (95% CI) | 0.71 (0.65 to 0.77) | 0.73 (0.67 to 0.78) | 0.72 (0.67 to 0.78) | 0.73 (0.67 to 0.78) | 0.73 (0.67 to 0.79) | 0.74 (0.68 to 0.80) |
NRI, categorical (<3%, 3% to 6%, >6%) | 0.09 (P=0.03) | 0.10 (P=0.01) | 0.13 (0.0002) | 0.09 (P=0.049) | 0.13 (P=0.004) |
Columns represent reclassification measures with addition of standardized LVMI, LVM/LVEDV, and RWT each added separately to CVD prediction model containing traditional CVD risk factors only, then added in combination to traditional CVD risk factor model (right-most 2 columns). CVD indicates cardiovascular disease; LVEDV, left ventricular end-diastolic volume; LVM, left ventricular mass; LVMI, left ventricular mass index; NRI, net reclassification improvement index; RWT, relative wall thickness.