Table 1.
Subject Characteristics at MESA Baseline (2000–2002) and CVD and Non-CVD ChrIRD Events During MESA Follow-up
| No. | Mean or % | SD | |
|---|---|---|---|
| Covariates | |||
| Age, y | 6475 | 62.1 | 10.3 |
| Race, % | |||
| White | 2508 | 38.7 | |
| Chinese | 787 | 12.2 | |
| Black | 1753 | 27.1 | |
| Hispanic | 1427 | 22.0 | |
| Female, % | 3425 | 52.9 | |
| Body mass index, kg/m² | 6475 | 28.3 | 5.4 |
| Systolic blood pressure, mm Hg | 6475 | 126.5 | 21.5 |
| Diastolic blood pressure, mm Hg | 6475 | 71.9 | 10.3 |
| Blood pressure–lowering medication, % | 2128 | 32.9 | |
| Cholesterol-lowering medication, % | 1048 | 16.2 | |
| Smoking | |||
| Current, % | 834 | 12.9 | |
| Former, % | 2367 | 36.6 | |
| Diabetes, % | 808 | 12.5 | |
| Biomarkers | |||
| Interleukin-6, pg/mL | 6475 | 1.55 | 1.22 |
| High-sensitivity C-reactive protein, mg/L | 6475 | 3.59 | 5.20 |
| D-dimer, μg/mL | 6475 | 0.36 | 0.77 |
| Lipids | |||
| Total cholesterol, mg/dL | 6475 | 194.2 | 35.4 |
| LDL cholesterol, mg/dL | 6397 | 117.3 | 31.4 |
| HDL cholesterol, mg/dL | 6475 | 51.0 | 14.8 |
| Triglycerides, mg/dL | 6475 | 130.5 | 78.1 |
| Lipoprotein particles | |||
| HDL particle family of variables | |||
| HS-P 7.3 to 8.2 nm, μmol/L | 6475 | 14.8 | 5.7 |
| HM-P 8.2 to 9.4 nm, μmol/L | 6475 | 13.3 | 6.9 |
| HL-P 9.4 to 14 nm, μmol/L | 6475 | 6.0 | 3.5 |
| HS-P+HM-P (HMS-P) 7.3 to 9.4 nm, μmol/L | 6475 | 28.1 | 5.5 |
| LDL particle family of variables | |||
| Large LDL 20.5 to 23 nm, nmol/L | 6475 | 587.6 | 259.3 |
| Small LDL 18 to 20.5 nm, nmol/L | 6475 | 535.0 | 382.0 |
| IDL 23 to 29 nm, nmol/L | 6475 | 125.9 | 98.5 |
| Small VLDL 29 to 35 nm, nmol/L | 6475 | 34.0 | 20.0 |
| Medium VLDL 35 to 60 nm, nmol/L | 6475 | 28.8 | 21.8 |
| Large VLDL >60 nm, nmol/L | 6475 | 5.0 | 6.5 |
| Events | |||
| CVD events, fatal or nonfatal, % | 756 | 11.7 | |
| ChrIRD, death or hospitalization, % | 1054 | 16.3 | |
| Both entities: CVD and ChrIRD, % | 345 | 5.3 | |
MESA indicates Multi-Ethnic Study of Atherosclerosis; CVD, cardiovascular disease; ChrIRD, noncardiovascular, noncancer chronic inflammation–related hospitalization and death; LDL, low-density lipoprotein; HDL, high-density lipoprotein; HS-P, small-diameter HDL particles; HM-P, medium-diameter HDL particles; HL-P, large-diameter HDL particles; IDL, intermediate-density lipoprotein; LDL, low-density lipoprotein; VLDL, very low-density lipoprotein.