Table 6.
Improvement in Prediction Probability for Model 3, Without (Base Model) and With Medium- Plus Small-Diameter HDL Particle Concentration (Alternative Model)
| Reclassification Down: % Events (n/N) | Reclassification Up: % Events (n/N) | Relative Risk | P Categorical Reclassification* | P Continuously Graded Reclassification† | |
|---|---|---|---|---|---|
| ChrIRD | 15.0 (486/3242) | 17.6 (568/3233) | 1.17 | 0.005 | <0.0001 |
| CVD | 11.3 (355/3145) | 12.0 (401/3330) | 1.06 | 0.34 | 0.13 |
| CHD | 6.0 (190/3187) | 7.1 (233/3288) | 1.18 | 0.07 | 0.25 |
| Stroke | 2.9 (88/3028) | 2.4 (84/3447) | 0.83 | 0.24 | 0.19 |
| HF | 3.3 (104/3078) | 3.5 (118/3397) | 1.06 | 0.83 | 0.22 |
HDL indicates high-density lipoprotein; ChrIRD, noncancer chronic inflammation–related hospitalization and death; CVD, cardiovascular disease; CHD, coronary heart disease; HF, heart failure.
*
P based on 2-sample z test for proportions comparing cumulative event rates for those reclassified up versus those reclassified down.
†
P for graded reclassification (Poisson regression of outcome on reclassification probability adjusted for base probability).