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. 2015 Jun 23;4(6):e001140. doi: 10.1161/JAHA.114.001140

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© 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Effect of incautious use of bias field correction on cortical infarct and WMH. The left image shows the original MR FLAIR image with a right frontal cortical infarct (arrow) and numerous WMH. Following bias field correction (left) the frontal infarct appears much smaller, some of the WMH have become more (eg, posterior areas) and some now appear split into smaller components (mid centrum semiovale) as the bias field smoothing software tries to “even out” the distribution of signal intensities across the image. FLAIR indicates fluid attenuation inversion recovery; MR, magnetic resonance; WMH, white matter hyperintensities.

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