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. 2015 Jun 12;4(6):e001712. doi: 10.1161/JAHA.114.001712

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© 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Zyxin^−/− stretched VSMCs display a disarray of F-actin stress fibers. A through D, F-actin stress fibers in control and stretched VSMCs (15% cyclic elongation for 1 hour) were stained with Alexa fluor 488-labeled phalloidin (white). Scale bar represents 50 μm. E, Quantification of F-actin fluorescence intensity in control and stretched VSMCs with zyxin-deficient VSMCs having prominent F-actin staining along the edges of the cells (white arrowheads in Figure 10C). **P<0.01, ***P<0.001 as indicated, n=3 for each group. F, The average number of condensed F-actin deposits (white arrows, D) within the cells was quantified. *P<0.05, **P<0.01 and ***P<0.001 as indicated, n.d. indicates not detectable, n=3 for each group. VSMCs indicates vascular smooth muscle cells; WT, wild type.