Figure 19.

Femoral arteries from old zyxin-null mice are less sensitive to changes in vessel diameter with increasing levels of perfusion pressure. A, Pressure-diameter readings in femoral arteries from 24-week-old wild-type (WT) and zyxin-null mice. Values were not significantly different between the 2 groups, n=5 for each group. B, Changes in vessel diameter in femoral arteries from 72-week-old WT and zyxin-null mice exposed to gradually increasing levels of perfusion pressure. *P<0.05, n=5 for femoral arteries from WT mice and n=3 for femoral arteries from zyxin-null mice. Differences in mean vessel diameter between the 2 groups at each data point were analyzed by an unpaired t test.