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. 2015 Jun 15;4(6):e001949. doi: 10.1161/JAHA.115.001949

Figure 3.

Figure 3

Ganglionic blockade reveals differences in sympathetic nerve activity in Ang II–infused control and TG SM-CaMKIIN mice. A, MAP after 2 weeks of Ang II infusion before and after administration of the ganglionic blocker CND. B, Decreases in MAP in (A) plotted as the difference before and after CND injection. C, Change in heart rate before and after CND injection. D, MAP after 2 weeks of Ang II infusion before and after administration of the vasodilator SNP. E, Decreases in MAP in (D) plotted as difference before and after SNP injection. F, Change in heart rate before and after SNP injection. G, MAP in saline-treated normotensive mice before and after administration of the ganglionic blocker CND. H, Decreases in MAP in (G) plotted as the difference before and after CND injection. I, Change in heart rate before and after CND injection. J, MAP after 2 weeks of Ang II infusion before and after administration of SNP. K, Decreases in MAP in (J) plotted as difference before and after SNP injection. L, Change in heart rate before and after SNP injection. M, Standard deviation of the systolic blood pressure over a 24-hour period on days 12 to 14 of saline or Ang II infusion (6 WT, 8 TG SM-CaMKIIN, 6 WT plus Ang II, 8 TG SM-CaMKIIN plus Ang II mice per group for A through K; 11 mice per group for M). *P<0.05. Ang II indicates angiotensin II; bpm, beats per minute; CND, chlorisondamine; MAP, mean arterial pressure; SNP, sodium nitroprusside; WT, wild type.