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. 2015 Jun 15;4(6):e001949. doi: 10.1161/JAHA.115.001949

Figure 4.

Figure 4

ADN recordings reveal differences in baroreceptor sensing in Ang II–infused TG SM-CaMKIIN and WT littermate aortas. A and B, Representative tracings of blood pressure and ADN activity in anesthetized WT mice demonstrate coupling between blood pressure and ADN firing. C and D, Baroreflex curves. Analysis of baroreceptor afferent function curves derived from ADN activity in response to intravenous infusion of SNP and PE in (C) WT and (D) TG SM-CaMKIIN mice. Studies were performed at 14 days after infusion of Ang II or saline. E and F, responses of (E) MAP and (F) heart rate to electric ADN stimulation (6 WT, 6 TG SM-CaMKIIN, 6 WT plus Ang II, 7 TG SM-CaMKIIN plus Ang II mice per group). ADN indicates aortic depressor nerve; Ang II, angiotensin II; MAP, mean arterial pressure; PE, phenylephrine; SNP, sodium nitroprusside; WT, wild type.