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CaMKII inhibition increases agonist-stimulated vasoconstriction following Ang II hypertension. Vasoconstriction of aortas to (A) KCl, (B) serotonin, and (C) phenylephrine, and (D) Ang II after infusion of Ang II or saline for 14 days (2 rings were analyzed per mouse and data were averaged; 7 WT, 5 TG SM-CaMKIIN, 5 WT plus Ang II, 5 TG SM-CaMKIIN plus Ang II mice per group). *P<0.05. Ang II indicates angiotensin II; CaMKII, calcium/calmodulin-dependent kinase II; WT, wild type.
