Table 3.
Univariate and Multivariable Logistic Regression Analysis for Isolated Nocturnal Hypertension (1=Normotension; 2=Isolated Nocturnal Hypertension) in Chinese CKD Patients
| Univariate Regression Analysis | Multivariable Regression Analysis | |||
|---|---|---|---|---|
| OR (95% CI) | P Value | OR (95% CI) | P Value | |
| Age (per 1 y) | 1.040 (1.028 to 1.051) | <0.001 | 1.021 (1.007 to 1.036) | 0.003 |
| Gender (male=1; female=2) | 1.011 (0.733 to 1.395) | 0.946 | ||
| Course (per 1 month) | 1.006 (1.002 to 1.011) | 0.003 | ||
| Diabetes mellitus (no=0, yes=1) | 2.714 (1.587 to 4.641) | <0.001 | ||
| Hemoglobin (per 1 g/L) | 0.982 (0.975 to 0.988) | <0.001 | ||
| Albumin (per 1 g/L) | 1.020 (1.001 to 1.039) | 0.040 | ||
| Calcium×phosphorus (per 1 mg2/dL2) | 1.032 (1.014 to 1.051) | 0.001 | ||
| iPTH (per 1 pg/mL) | 1.003 (1.001 to 1.004) | <0.001 | ||
| Serum fasting glucose (per 1 mmol/L) | 1.152 (1.020 to 1.302) | 0.022 | ||
| Cholesterol (per 1 mmol/L) | 0.920 (0.864 to 0.980) | 0.010 | ||
| HDL-C (per 1 mmol/L) | 0.382 (0.253 to 0.576) | <0.001 | ||
| LDL-C (per 1 mmol/L) | 0.874 (0.805 to 0.949) | 0.001 | ||
| Uric acid (per 1 mmol/L) | 1.003 (1.002 to 1.005) | <0.001 | ||
| Urinary sodium excretion (per 1 mmol/24 h) | 0.999 (0.996 to 1.003) | 0.636 | ||
| eGFR-MDRD (per 1 mL/min per 1.73 m2) | 0.985 (0.981 to 0.988) | <0.001 | 0.989 (0.984 to 0.993) | <0.001 |
| Clinic-SBP (per 1 mm Hg) | 1.039 (1.029 to 1.049) | <0.001 | ||
| Clinic-DBP (per 1 mm Hg) | 1.059 (1.043 to 1.076) | <0.001 | 1.060 (1.041 to 1.079) | <0.001 |
Adjusted variables: age, gender (male=1, female=2). Variables of univariate regression analysis include course, diabetes mellitus (no=0, yes=1), current smoker (no=0, yes=1), alcohol intake (no=0, yes=1), BMI, hemoglobin, albumin, calcium×phosphorus, iPTH, serum fasting glucose, cholesterol, triglyceride, HDL-C, LDL-C, uric acid, Lg(proteinuria), urinary sodium excretion, eGFR, clinic-SBP, and clinic-DBP. All variables with significant associations were included in multivariable regression analysis. BMI indicates body mass index; CKD, chronic kidney disease; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; HDL-C, high-density lipoprotein cholesterol; iPTH, intact parathyroid hormone; LDL-C, low-density lipoprotein cholesterol; Lg, Logarithm; MDRD, Modification of Diet in Renal Disease; OR, odds ratio; SBP: systolic blood pressure.