Table 3.
Outcome title | No of studies | No of participants | Statistical method | Effect size | P-value |
---|---|---|---|---|---|
Mortality | 9 | 269 | Risk ratio (M–H, fixed, 95% CI) | 0.41 (0.07, 2.29) | 0.31 |
Pruritus | 4 | 131 | Risk ratio (M–H, fixed, 95% CI) | 1.60 (0.90, 2.85) | 0.11 |
Adverse events | Risk ratio | ||||
1. Permanent discontinuation of treatment | 2 | 83 | (M–H, fixed, 95% CI) | 0.14 (0.02, 1.08) | 0.06 |
2. Not necessitating permanent discontinuation of treatment | 9 | 269 | 0.29 (0.08, 1.08) | 0.06 | |
Mayo risk score | 2 | 60 | Mean difference (IV, fixed, 95% CI) | 0.60 (0.25, 0.95) | 0.0008 |
Alkaline phosphatase | Mean difference | ||||
1. Trial duration ≤24 months | 6 | 171 | (IV, random, 95% CI) | −255.57 (−301.38, −209.77) | <0.0001 |
2. Trial duration >24 months | 3 | 76 | −191.35 (−263.62, −119.08) | <0.0001 | |
Gamma-glutamyltransferase | Mean difference | ||||
1. Change from baseline | 3 | 57 | (IV, fixed, 95% CI) | −15.47 (−32.11, 1.18) | 0.07 |
2. Final measurement values | 4 | 137 | −66.41 (−84.93, −47.88) | <0.0001 | |
Alanine aminotransferase | Mean difference | ||||
1. Trial duration ≤24 months | 3 | 75 | (IV, fixed, 95% CI) | −14.89 (−21.07, −8.71) | <0.0001 |
2. Trial duration >24 months | 1 | 37 | −9.40 (−12.02, −6.78) | <0.0001 | |
Immunoglobulin M | Mean difference | ||||
1. Trial duration ≤24 months | 5 | 162 | (IV, fixed, 95% CI) | −82.22 (−108.76, −55.68) | <0.0001 |
2. Trial duration >24 months | 1 | 37 | −264.70 (−310.15, −219.25) | <0.0001 | |
Triglycerides | 4 | 115 | Mean difference (IV, fixed, 95% CI) | −26.84 (−36.51, −17.17) | <0.0001 |
Total cholesterol | 4 | 115 | Mean difference (IV, fixed, 95% CI) | −21.58 (−30.81, −12.34) | <0.0001 |
Serum bilirubin | 4 | 97 | Mean difference (IV, fixed, 95% CI) | −0.20 (−0.33, −0.07) | 0.002 |
Albumin | 2 | 63 | Mean difference (IV, fixed, 95% CI) | −0.09 (−0.27, 0.10) | 0.35 |
AST | 2 | 39 | Mean difference (IV, fixed, 95% CI) | 4.53 (−2.54, 11.60) | 0.21 |
Abbreviations: AST, aspartate aminotransferase; M–H, Mantel–Haenszel; CI, confidence interval; IV, inverse-variance.